Medical Laboratory Scientist – Stem Cell at The African Medical Centre of Excellence (AMCE)

Job Purpose

• The Medical Laboratory Scientist – Stem Cell will be responsible for executing, managing, and optimising experiments related to stem cell biology, cellular reprogramming, differentiation, and regenerative medicine. The role holder will conduct technical laboratory examinations, manage data analysis, and contribute to a multidisciplinary research environment to advance stem cell science and its clinical applications.

Key Accountabilities/Responsibilities

Experimental Design and Execution

• Develop and implement experimental plans, including hypothesis development, protocol design, and project timelines.
• Optimise protocols for stem cell isolation, culture, expansion, differentiation, and maintenance.
• Conduct cellular reprogramming using advanced methodologies (e.g., Yamanaka factors, episomal vectors).
• Differentiate stem cells into specific cell types such as neurons, cardiomyocytes, and hepatocytes.
• Apply gene-editing technologies (e.g., CRISPR/Cas9) to advance functional studies.
• Perform immunocytochemistry, flow cytometry, and high-throughput assays to evaluate phenotypes.

Quality Assurance and Compliance

• Monitor cell morphology, proliferation, and viability to ensure consistent, high-quality stem cell cultures.
• Perform contamination checks, including routine mycoplasma testing.
• Adhere to Good Manufacturing Practice (GMP), FDA, and international ethical standards.
• Prepare and maintain Standard Operating Procedures (SOPs), risk assessments, and safety protocols.

Data Collection and Analysis

• Maintain accurate data using electronic laboratory notebooks and software.
• Perform statistical analysis to validate results and trends.
• Use bioinformatics tools for omics data analysis, including RNA-seq and single-cell sequencing.
• Prepare research reports, presentations, and visual data for internal and external stakeholders.

Collaboration and Communication

• Collaborate with clinicians, molecular biologists, and bioinformaticians on research projects.
• Participate in team meetings, cross-disciplinary initiatives, and grant applications.
• Contribute to manuscripts for peer-reviewed journals and present findings at conferences.

Laboratory Management and Mentorship

• Manage laboratory stocks, reagents, and equipment maintenance.
• Train and mentor junior staff, interns, and technicians in stem cell techniques.
• Provide quality assurance oversight for laboratory operations and experimental reproducibility.

Qualifications

• Bachelor’s degree in Microbiology, Medical Laboratory Science, Biology, Chemistry, Biochemistry, or related field.
• Master’s degree in a related discipline is an added advantage.
• Certification as a Technologist or Specialist in Microbiology is an advantage.

Experience

• 1–4 years’ experience in a stem cell laboratory setting.
• Proven expertise in stem cell isolation, differentiation, and characterisation.
• Experience with molecular biology techniques such as PCR, flow cytometry, and immunohistochemistry.
• Strong knowledge of stem cell biology, including pluripotent and adult stem cells.
• Proficiency in advanced cell culture and molecular techniques.
• Understanding of ethical, regulatory, and safety considerations in stem cell research.
• Familiarity with experimental design, data analysis, and scientific reporting.
• Up-to-date knowledge of trends and advancements in regenerative medicine and stem cell applications.