Senior Program Officer - INSPIRE at Institute of Human Virology, Nigeria

Summary / Overview

• The Senior Program Officer (Drug Level Analyst),INSPIRE NIH R01 – 1R01AI147331-01, will take part in the research and routine analytical work in the virology section.
• The focus of the drug level analyst is to provide a quantitative measure of drugs and/or their metabolites for the purpose of pharmacokinetic, bioequivalence, metabolism and exposure-response (pharmacokinetic / pharmacodynamics) studies.
• S/he will develop, validate, and maintain state-of-the-art quantitative assays to support research and clinical care for researchers and use his/her expertise in pharmacology, pharmacokinetics, pharmacodynamics, genetics, and genomics to help investigators develop scientific protocols and to help clinicians optimize drug therapy in patients.
• The person will be expected to work following Good Clinical Laboratory Practice (GCLP) and safety guidelines.
• S/he will also do other duties as assigned by the Head of the Unit.

Essential Functions

• Develop and implement analytical assays to assess the compartmentalized pharmacokinetics of anti-infective agents in the prevention and/or management of HIV/AIDS.
• Carry out the quantification of small molecules using liquid chromatographic-tandem mass spectrometric (LC-MS/MS) analyses.
• Measure concentrations of the compound of interest in samples.
• Validate assays as per US Food and Drug Administration guidelines, Guidance for Industry: Bioanalytical Method Validation recommendations.
• Participate in population pharmacokinetic analysis of the data.
• Prepare budgets and supply orders.
• Adhere to / enforce good research and laboratory practice including Quality Assurance/Quality Control
• Provide monthly/regular updates of progress to both senior and junior staff
• Provide technical expertise in support of laboratory components for the study and other research studies as assigned by the Principal Investigator (PI).
• Participate in the execution of targets within project stipulated time lines in conjunction with the PI

Qualification / Skills

• Must hold a Ph.D. /MSc. in Chemistry with at least 3-5 years of experience.
• She/he should have worked in an active research laboratory especially in drug level analysis.
• Expert in the pre-analytical, analytical, and post-analytical stages of the total testing processes.